Nanodelivery of natural isothiocyanates as a cancer therapeutic

Natural isothiocyanates (ITCs) are phytochemicals abundant in cruciferous vegetables with the general structure, R–NCS. They bioactive organosulfur compounds derived from hydrolysis of glucosinolates by myrosinase. A significant number have been isolated different plant sources that include broccoli, Brussels sprouts, cabbage, cauliflower, kale, mustard, wasabi, and watercress. Several ITCs demonstrated to possess pharmacological properties including: antioxidant, anti-inflammatory, anti-cancer antimicrobial activities. Due their chemopreventive effects on many types cancer, regarded as a promising therapeutic agent without major toxicity concerns. However, clinical application has hindered several factors including low aqueous solubility, bioavailability, instability well hormetic effect. Moreover, typical dietary uptake consumed for promotion good health may be far (or cytotoxic) dose necessary cancer prevention and/or treatment. Nanotechnology is one best options attain enhanced efficacy minimize effect ITCs. Nanoformulation leads enhance stability plasma emphasize effects. This review provides summary potential bioactivities ITCs, mechanisms action treatment recent research progress nanodelivery strategies efficacy.